P1 peptide

P1 peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-AVPYPQ-OH

H-Ala-Val-Pro-Tyr-Pro-Gln-OH

6

95.01%

C₃₂H₄₇N₇O₉

673.75

Synthetic

Powder

P1 peptide(AVPYPQ) exhibited strong antioxidant potential against in vitro radicals with IC50 values for DPPH (5.12 ± 0.9-12.54 ± 0.6 µg/ml), ABTS (5.97 ± 0.2-14.20 ± 1.5 µg/ml), FRAP (4.98 ± 2.2-12.19 ± 0.8 µg/ml) and PSC (9.71 ± 0.5-17.84 ± 1.3 µg/ml),respectively. This peptide reduced ROS concentrations in Caco-2 cells treated with hydrogen peroxide. In silico studies indicated P1 had a higher binding score for the Keap1-Kelch domain than TX6, a potential Keap1 reference ligand.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Tyagi A, Chelliah R, Banan-Mwine Daliri E, Sultan G, Madar IH, Kim N, et al. Antioxidant activities of novel peptides from Limosilactobacillus reuteri fermented brown rice: A combined in vitro and in silico study. Food Chem. 2023;404(Pt B):134747

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.