Human OBCAM/OPCML (His Tag) recombinant protein

Human OBCAM/OPCML (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Opioid-binding Cell Adhesion Molecule (OBCAM), also known as OPCML, is a GPI-anchored cell adhesion molecule in the plasma membrane. This neuron-specific protein, consists of three immunoglobulin (Ig)-like domains anchored to the membrane through a glycosylphosphatidylinositol (GPI)-tail. OPCML also belongs to the member of the IgLON family, a subgroup of the immunoglobulin superfamily, consisting of three members, LAMP, OBCAM, and Neurotrimin. These molecules interact homophilically and heterophilically within the family, and OBCAM acts only as heterodimers with LAMP or Neurotrimin and possibly inhibits neurite outgrowth from cerebellar granule cells. OBCAM has been presumed to play a role as a cell adhesion/recognition molecule. Furthermore, the OPCML protein defects may play an important role in the carcinogenesis of cervical or ovarian cancers, and this gene is regarded as a candidate TSG (tumor suppressor gene).

Opioid binding protein/cell adhesion molecule-like preprotein isoform a

IGLON1; OPCM; 3732419F12; GM181; AI844366; OBCAM; OPCML; C230027C17; MGC99974; B930023M13RIK; 2900075O15RIK

Q14982

OPCML; hCG_1811667

Human Cells

A DNA sequence encoding the human OPCML precursor (NP_002536.1) (Met 1-Asn 322) was expressed with a C-terminal polyhistidine tag.

Human

The mature recombinant human OPCML consists of 306 amino acids and has a calculated molecular mass of 34 kDa. As a result of glycosylation, rhOPCML migrates as an approximately 55-60 kDa protein in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE