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Product Name
Recombinant ODO2 protein (His tag)
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Description
Recombinant Human DLST Protein Fragment (aa 70-145) - A high-purity recombinant protein fragment encompassing the essential lipoyl-binding domain of dihydrolipoyllysine-residue succinyltransferase (OGDC-E2), designed for functional studies of mitochondrial metabolism and nuclear epigenetic regulation.
The full-length DLST protein serves as the dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex, which catalyzes the conversion of 2-oxoglutarate to succinyl-CoA and CO₂. This complex primarily functions in the mitochondrial matrix, playing a crucial role in the citric acid cycle. Notably, recent research has revealed that a fraction of the complex also localizes to the nucleus, where it associates with histone acetyltransferase KAT2A and provides succinyl-CoA for histone succinylation, linking mitochondrial metabolism to epigenetic regulation. The provided fragment specifically contains the lipoyl-binding domain, making it an ideal tool for investigating the molecular mechanisms underlying these dual cellular functions.
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Protein name
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
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Uniprot ID
P36957
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Gene Name
DLST; DLTS
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 70-145 aa (P36957) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 9.65 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 11 kDa band.
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Purity
>86%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"