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Product Name
OCA2 Polyclonal Antibody
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Description
Polyclonal antibody to OCA2
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Tested applications
WB
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Species reactivity
Human
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Alternative names
OCA2 antibody; BEY antibody; BEY1 antibody; BEY2 antibody; BOCA antibody; D15S12 antibody; EYCL antibody; EYCL2 antibody; EYCL3 antibody; HCL3 antibody; P antibody; PED antibody; SHEP1 antibody; P protein antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human OCA2 (NP_000266.2).
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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Storage instructions
Store at -20℃. Avoid freeze / thaw cycles.
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Applications
WB 1:500 - 1:2000
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Validations
Western blot - OCA2 Polyclonal Antibody
Western blot analysis of extracts of various cell lines, using OCA2 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.
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Background
Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"