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  • Obestatin (human) peptide

Obestatin (human) peptide

Not For Human Use, Lab Use Only.

Cat.#: 310680

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* Buy 1 get 1 free (?) What is TFA?

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Product Information

  • Product Name
    Obestatin (human) peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    FNAPFDVGIKLSGVQYQQHSQAL-NH2
  • Sequence
    H-Phe-Asn-Ala-Pro-Phe-Asp-Val-Gly-Ile-Lys-Leu-Ser-Gly-Val-Gln-Tyr-Gln-Gln-His-Ser-Gln-Ala-Leu-NH2
  • Length (aa)
    23
  • Peptide Purity (HPLC)
    98.67%
  • Molecular Formula
    C116H176N32O33
  • Molecular Weight
    2546.84
  • Source
    Synthetic
  • Form
    Powder
  • Description

    Obestatin is a 23-amino acid peptide hormone derived from the same preproghrelin gene through posttranslational processing. It is characterized by a C-terminal amidation, which is essential for its biological activity. This peptide was identified bioinformatically based on conserved regions flanked by convertase cleavage sites in mammalian preproghrelin sequences.

    Obestatin functions as an endogenous ligand for the orphan G protein-coupled receptor GPR39, activating signaling pathways such as cAMP production. In contrast to ghrelin, obestatin suppresses food intake, inhibits jejunal contraction, and reduces body weight gain. It is primarily produced in the stomach and circulates in distinct molecular forms, including a full-length amidated peptide and processed fragments.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Zhang JV, Ren PG, Avsian-Kretchmer O, Luo CW, Rauch R, Klein C, Hsueh AJ. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science. 2005 Nov 11;310(5750):996-9. doi: 10.1126/science.1117255. PMID: 16284174.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"