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Product Name
Recombinant OAZ protein (His tag)
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Description
Recombinant Ornithine Decarboxylase Antizyme (ODC-Az) Fragment (residues 52-159) from Caenorhabditis elegans, a stable and soluble protein unit ideal for structural and biochemical studies of polyamine biosynthesis regulation.
Ornithine decarboxylase antizyme (ODC-Az), encoded by the oaz-1 gene, is a key regulatory protein that controls intracellular polyamine levels by negatively modulating ornithine decarboxylase (ODC) activity. It binds to ODC monomers, preventing the formation of functional homodimers and targeting them for ubiquitin-independent degradation via the 26S proteasome. This mechanism helps maintain polyamine homeostasis in response to fluctuating intracellular concentrations, underscoring its importance in cellular metabolism and potential research applications in studying polyamine-related pathways.
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Protein name
Ornithine decarboxylase antizyme
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Uniprot ID
Q9NHZ6
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Gene Name
oaz-1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 52-159 aa (Q9NHZ6) were fused with 6His tag.
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Protein Species
Caenorhabditis elegans
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Molecular weight
Predictes a molecular mass of 14.05 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 14 kDa band.
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Purity
>89%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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