Recombinant NUDT4 protein (His tag)

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Recombinant Human Diphosphoinositol Polyphosphate Phosphohydrolase 2 (DIPP-2) Fragment (NUDT4, aa 1-145) – A high-purity protein fragment engineered to encompass the complete Nudix hydrolase domain, enabling targeted investigation into diphosphoinositol polyphosphate metabolism and signaling pathways.

Diphosphoinositol polyphosphate phosphohydrolase 2 (DIPP-2), encoded by the NUDT4 gene, is a multifunctional enzyme that cleaves the beta-phosphate from key signaling molecules, including diphosphoinositol pentakisphosphate (PP-InsP5), diphosphoinositol tetrakisphosphate (PP-InsP4), and bisdiphosphoinositol tetrakisphosphate ([PP]2-InsP4), suggesting a critical role in inositol pyrophosphate-mediated signal transduction. It also hydrolyzes diadenosine polyphosphates such as Ap6A and Ap5A—effectors in cardiac KATP channel regulation—and converts 5-phosphoribose 1-diphosphate to ribose 1,5-bisphosphate, a glycolytic activator. While it binds U8 snoRNA, it does not participate in U8 snoRNA decapping. The protein is localized to the cytoplasm, where it likely modulates cellular signaling and metabolic processes.