Recombinant NSD2 protein (His tag)

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Recombinant Human NSD2 PWWP Domain Fragment (aa 219-347) - A high-purity protein fragment encompassing the conserved PWWP domain of Histone-lysine N-methyltransferase NSD2, designed for studying domain-specific interactions in epigenetic regulation and chromatin biology.

Histone-lysine N-methyltransferase NSD2 (also known as MMSET or WHSC1) is a crucial epigenetic regulator that specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2), playing essential roles in gene transcription control during development, immune cell differentiation, and cellular specialization. The full-length protein localizes to the nucleus and chromosomes, where it participates in diverse biological processes including adipogenesis, T-cell and B-cell development, and class switch recombination of the immunoglobulin heavy chain locus. The provided fragment (amino acids 219-347) contains the PWWP domain (222-286), a conserved structural motif known to mediate chromatin interactions, making this recombinant protein an ideal tool for investigating domain-specific functions in epigenetic mechanisms and chromatin binding studies.