Recombinant NRCAM protein (His tag)

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This recombinant protein product features a stable and soluble 86-amino acid fragment (residues 1082-1167) of human Neuronal cell adhesion molecule (Nr-CAM), designed for structural and biochemical studies. Nr-CAM is essential for neuronal development, cell adhesion, and the organization of nodes of Ranvier, making this fragment an ideal tool for investigating its molecular mechanisms in neuroscience research.

Neuronal cell adhesion molecule (Nr-CAM) is a cell adhesion protein critical for normal cell-cell interactions in the brain and peripheral nervous system. It facilitates neurite outgrowth upon binding to contactin and mediates contacts between Schwann cells and axons. Nr-CAM plays a key role in the formation and maintenance of nodes of Ranvier, which are specialized axonal regions containing clustered sodium channels necessary for saltatory action potential propagation in myelinated axons. During development, it is involved in clustering sodium channels at heminodes, and in mature nodes, it works alongside GLDN to sustain NFASC and sodium channel clusters. Located at the cell membrane, particularly in axonal projections, and also secreted, Nr-CAM is detected at nodes of Ranvier, underscoring its importance in neural connectivity and function.