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Product Name
Recombinant NOXA1 protein (His tag)
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Description
This recombinant protein product features a fragment (amino acids 312-476) of human NADPH oxidase activator 1 (NOXA1), encompassing the complete PB1 and SH3 domains. It serves as a specialized tool for investigating the domain-specific mechanisms of NOX1 activation and reactive oxygen species (ROS) production, supporting research in signal transduction, host defense, and oxidative stress pathways.
NOXA1 functions as a key activator of NOX1, a superoxide-producing NADPH oxidase involved in generating reactive oxygen species (ROS). These ROS play critical roles in biological processes such as host defense, hormone biosynthesis, oxygen sensing, and signal transduction. NOXA1 may also activate other NADPH oxidases like CYBB/gp91phox and NOX3. The protein is primarily localized in the cytoplasm and translocates to the cell membrane in a process dependent on NOXO1 or NCF1 and potentially RAC1, facilitating its role in redox signaling and cellular responses.
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Protein name
NADPH oxidase activator 1
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Uniprot ID
Q86UR1
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Gene Name
NOXA1; P51NOX
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 312-476 aa (Q86UR1) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 19.38 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 19 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"