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  • Nonapeptide-1

Nonapeptide-1

Not For Human Use, Lab Use Only.

Cat.#: 319285

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* Buy 1 get 1 free (?) What is TFA?

Special Price 94.20 USD

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Product Information

  • Product Name
    Nonapeptide-1
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    H-MPfRwFKPV-NH2, f=D-Phe, w=D-Trp
  • Sequence
    H-Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2
  • Length (aa)
    9
  • Peptide Purity (HPLC)
    95.86%
  • Molecular Formula
    C61H87N15O9S
  • Molecular Weight
    1206.5
  • Source
    Synthetic
  • Form
    Powder
  • Description

    Nonapeptide-1, identified as Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2, is a potent antagonist of the α-melanocyte-stimulating hormone (α-MSH) receptor. This peptide was discovered through the screening of a multi-use peptide library based on the α-MSH-[5-13] sequence. Structural analysis revealed that residues at positions 5-6, 7-9, and 10 are critical for its antagonistic activity, with D-Trp5 and Phe6 playing pivotal roles in receptor inactivation. The peptide exhibits an IC50 value of 11.7 nM, demonstrating its high potency in blocking α-MSH receptor function.

    The design of Nonapeptide-1 incorporates modifications in chirality and amino acid composition, particularly the D-Phe-L-Arg-D-Trp segment, which significantly enhances its antagonistic properties. The presence of L-Phe at position 10 further contributes to its efficacy. This peptide serves as a valuable tool for studying melanotropin receptor interactions and elucidating the structural determinants required for receptor antagonism.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Jayawickreme CK, Quillan JM, Graminski GF, Lerner MR. Discovery and structure-function analysis of alpha-melanocyte-stimulating hormone antagonists. J Biol Chem. 1994 Nov 25;269(47):29846-54. PMID: 7961978.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"