Recombinant NOA1 protein (His tag)

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Recombinant Nitric Oxide-Associated Protein 1 (NOA1) Fragment (residues 90-447), derived from Homo sapiens, is a stable and soluble 358-amino acid protein designed for structural and biochemical studies. This fragment supports research into mitochondrial protein translation, respiration, and cell death regulation, offering a reliable tool for exploring NOA1's role in cellular energy and apoptosis pathways.

Nitric Oxide-Associated Protein 1 (NOA1) is a human protein localized to the mitochondrial inner membrane, specifically on the matrix side, where it functions as a peripheral membrane protein. It plays a critical role in regulating mitochondrial protein translation and respiration, contributing to cellular energy production. Additionally, NOA1 is involved in mitochondria-mediated cell death, potentially acting as a scaffolding protein or stabilizer of respiratory chain supercomplexes, and it binds GTP, indicating its involvement in nucleotide-dependent processes. This protein's functions are essential for understanding mitochondrial dynamics and apoptosis mechanisms in health and disease.