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  • Nicastrin antibody
  • Nicastrin antibody

Nicastrin antibody

Cat.#: 113181

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Product Information

  • Product Name
    Nicastrin antibody
  • Documents
  • Description
    Nicastrin Rabbit Polyclonal antibody. Positive WB detected in mouse brain tissue, C6 cells, human brain tissue. Positive IF detected in C6 cells. Observed molecular weight by Western-blot: 110kd
  • Tested applications
    ELISA, WB, IF
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    APH2 antibody; KIAA0253 antibody; NCSTN antibody; nicastrin antibody
  • Isotype
    IgG
  • Preparation
    This antibody was obtained by immunization of Nicastrin recombinant protein (Accession Number: BC047621). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IF: 1:10-1:100

  • Validations

    mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:113181(NCSTN antibody) at dilution of 1:800

    mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:113181(NCSTN antibody) at dilution of 1:800

    Immunofluorescent analysis of C6 cells using Catalog No:113181(Nicastrin Antibody) at dilution of 1:25 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

    Immunofluorescent analysis of C6 cells using Catalog No:113181(Nicastrin Antibody) at dilution of 1:25 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

  • Background
    Nicastrin (NCT) is a type I transmembrane glycoprotein, which forms high molecular weight gamma-secretase complexes with with presenilin 1 and presenilin 2 (PMID: 16096051). The gamma-secretase is an intramembrane protease cleaves many type I membrane proteins including amyloid precursor protein (APP) and Notch, generating peptide fragments that are important signaling components (PMID: 16096062). The proteolytical processing of APP results in the release of amyloid-βpeptide, a principal component of the plaques found in the brains of Alzheimer’s disease patients (PMID: 12716934).
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"