NFKB2,p52,p100-Specific antibody

Cat.#: 113158

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Product Information

  • Product Name
    NFKB2,p52,p100-Specific antibody
  • Documents
  • Description
    NFKB2,p52,p100-Specific Rabbit Polyclonal antibody. Positive IHC detected in human testis tissue, human brain tissue, human kidney tissue, human lung tissue, human ovary tissue, human placenta tissue, human spleen tissue. Positive WB detected in A431 cells, HeLa cells, MCF-7 cells, mouse heart tissue. Observed molecular weight by Western-blot: 52/100kd
  • Tested applications
    ELISA, IHC, WB
  • Species reactivity
    Human, Mouse; other species not tested.
  • Alternative names
    DNA binding factor KBF2 antibody; H2TF1 antibody; LYT 10 antibody; LYT10 antibody; NFKB2 antibody; NFKB2 antibody; p100 antibody; NFKB2 antibody; p52 antibody; p100 antibody; Oncogene Lyt 10 antibody; p100 antibody; p52 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of Peptide (Accession Number: NM_001077494). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    Immunohistochemical of paraffin-embedded human testis using Catalog No:113158(NFKB2,p52,p100-Specific antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemical of paraffin-embedded human testis using Catalog No:113158(NFKB2,p52,p100-Specific antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemical of paraffin-embedded human spleen using Catalog No:113158(NFKB2,p52,p100-Specific antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemical of paraffin-embedded human spleen using Catalog No:113158(NFKB2,p52,p100-Specific antibody) at dilution of 1:50 (under 40x lens)

    A431 cells were subjected to SDS PAGE followed by western blot with Catalog No:113158(NFKB2,p52,p100-Specific Antibody) at dilution of 1:600

    A431 cells were subjected to SDS PAGE followed by western blot with Catalog No:113158(NFKB2,p52,p100-Specific Antibody) at dilution of 1:600

  • Background
    NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. P52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. P52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. This antibody can bind both p52 and p100 isoforms of NFKB2.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"