Neurotensin peptide

Neurotensin peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

Pyr-LYENKPRRPYIL-OH

Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH

12

95.56%

C₇₈H₁₂₁N₂₁O₂₀

1672.92

Synthetic

Powder

This peptide is bovine neurotensin, which contains an N-terminal pyroglutamic acid. Neurotensin is a 13 amino acid neuropeptide first isolated from bovine hypothalamus. It was detected in the central nervous system (CNS) and peripheral tissues mainly in the gastrointestinal tract, where it inducessmooth muscle contraction. In the CNS, neurotensin has a dual function of neuromodulator of dopamine transmission and of anterior pituitary hormone secretion. It also shows potent hypothermic and analgesic effects in the brain. Neurotensin has been implicated in the pathophysiology of schizophrenia, Huntington, and Parkinson diseases.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Gullo L, De Giorgio R, Corinaldesi R, Barbara L. Neurotensin: a physiological regulator of exocrine pancreatic secretion? Ital J Gastroenterol. 1992 Jul-Aug;24(6):347-51. PMID: 1515662.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.