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Product Name
Human Neuropilin-1/NRP1/CD304 (Fc Tag) recombinant protein
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Description
The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.
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Protein name
Neuropilin-1
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Protein short names
DKFZP686A03134; NPN1; NPN-1; C530029I03; BDCA4; NRP1; NP-1; RP11-342D11.1; NRP; NP1; DKFZP781F1414; CD304; VEGF165R; NEUROPILIN-1
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Uniprot ID
Q68DN3
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Gene Name
NRP1; NRP; VEGF165R
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human NRP1 isoform b (NP_001019799.1) (Met 1-Lys 644) was expressed with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human NRP1/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 861 amino acids and has a calculated molecular mass of 96.5 kDa. As a result of glycosylation, rh NRP1/Fc monomer migrates as an approximately 120-125 kDa protein in SDS-PAGE under reducing conditions.
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Purity
> 85 % as determined by SDS-PAGE
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Activity
Measured by its ability to bind with recombinant human VEGF165 in a functional ELISA.
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Validations
Human Neuropilin-1 / NRP1 Protein (Fc Tag) SDS-PAGE
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