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  • Neuropeptide RFRP-2

Neuropeptide RFRP-2

Cat.#: 306938

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Optional Service: TFA RemovalWhat's this?

Special Price 207.0 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    Neuropeptide RFRP-2
  • Documents
  • Quantity/Unit
    1 Vial
  • Sequence
    ANMEAGTMSHFPSLPQRF
  • Three letter code
    H-Ala-Asn-Met-Glu-Ala-Gly-Thr-Met-Ser-His-Phe-Pro-Ser-Leu-Pro-Gln-Arg-Phe-NH2
  • Length (aa)
    18
  • Peptide Purity (HPLC)
    96.7
  • Molecular Formula
    C88H134N26O25S2
  • Molecular Weight
    2020.2
  • Source
    Synthetic
  • Additional Information
    This peptide belongs to a family of RFamide peptides termed RFamide-related peptides (RFRPs), reported to be present in the mammalian brain. The preproprotein of rat RFRPs contains two putative peptides RFRP-1 and RFRP-2 and it could be demonstrated by K.Ukena et al., that this octadecapeptide represents the mature form of RFPR-2 in the rat hypothalamus.
  • Storage Guidelines
    Ideally Neuropeptide RFRP-2 should be stored in a freezer at or below -9C. Neuropeptide RFRP-2 should be refrigerated after reconstitution. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • S.Hinuma et al., Nat. Cell Biol., 2, 703 (2000)
    • K.Ukena et al., FEBS Lett., 512, 255 (2000)
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

Peptide Property

  • Analysed Sequence:H-ANMEAGTMSHFPSLPQRF-Amidation
  • Chemical Formula:C88H134N26O25S2
  • Sequence length:18
  • Extinction coefficient:0 M-1cm-1
  • GRAVY:-0.41
  • Mw average:2020.28
  • Theoretical pI:7.88
  • Data Source:Peptide Property Calculator

GRAVY = grand average of hydropathy

Red: Hydrophobic uncharged residues, like F I L M V W A and P

Blue: Basic residues, like R K H and N-terminal -NH2

Green: Acidic residues, like D E and C-terminal -COOH

Black: Polar uncharged residues, like G S T C N Q and Y

Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"