Neuropeptide-glutamic acid-isoleucine, Neuropeptide EI (human, mouse, rat)
Not For Human Use, Lab Use Only.
Cat.#: 304903
Special Price 164.50 USD
Availability:
1-2 weeks
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Product Name
Neuropeptide-glutamic acid-isoleucine, Neuropeptide EI (human, mouse, rat)
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Documents
Batch to batch variation of the purity
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Sequence Shortening
EIGDEENSAKFPI-NH2
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Sequence
H-Glu-Ile-Gly-Asp-Glu-Glu-Asn-Ser-Ala-Lys-Phe-Pro-Ile-NH2
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Length (aa)
13
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Peptide Purity (HPLC)
97.6%
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Molecular Formula
C63H98N16O23
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Molecular Weight
1447.6
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CAS No.
125934-45-4
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Source
Synthetic
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Form
Powder
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Description
Neuropeptide-glutamic acid-isoleucine (NEI) is a neuropeptide derived from the post-translational cleavage of the prepro-melanin-concentrating hormone (ppMCH) precursor. This processing, which involves specific prohormone convertases such as PC2 and carboxypeptidase E, results in an amidated peptide. NEI is extensively colocalized with melanin-concentrating hormone (MCH) in neurons of the lateral hypothalamic area and the incerto-hypothalamic area, with broad projections throughout the central nervous system. It is also present in several peripheral tissues, including the testes.
Functionally, NEI is involved in the regulation of neuroendocrine and behavioral processes. It stimulates the release of luteinizing hormone (LH) from the pituitary gland, acting both directly on gonadotropes and by modulating gonadotropin-releasing hormone (GnRH) neurons. Furthermore, central administration of NEI induces specific behaviors, such as excessive grooming and increased locomotor activity, effects that are associated with alterations in catecholamine metabolism in brain regions like the nucleus accumbens and caudate putamen.
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Storage Guidelines
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
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References
- M.-T.Bluet-Pajot et al., J. Neuroendocrinol., 7, 297 (1995)
- Bittencourt J, Celis ME. Anatomy, function and regulation of neuropeptide EI (NEI). Peptides. 2008 Aug;29(8):1441-50. doi: 10.1016/j.peptides.2008.03.012. Epub 2008 Mar 21. PMID: 18456371.
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About TFA salt
Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.
Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.
Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.
In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.
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Molar Concentration Calculator
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Dilution Calculator
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Percent Concentration Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"