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  • Neurokinin A peptide

Neurokinin A peptide

Not For Human Use, Lab Use Only.

Cat.#: 315918

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* Buy 1 get 1 free (?) What is TFA?

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Product Information

  • Product Name
    Neurokinin A peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    HKTDSFVGLM
  • Sequence
    His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2
  • Length (aa)
    10
  • Peptide Purity (HPLC)
    96.9%
  • Molecular Formula
    C50H80N14O14S
  • Molecular Weight
    1133.34
  • CAS No.
    86933-74-6
  • PubChem CID
    5311311
  • Source
    Synthetic
  • Form
    Powder
  • Description

    Neurokinin A (NKA), also known as substance K, is a peptide neurotransmitter belonging to the tachykinin family. It is characterized by a conserved COOH-terminal sequence, Phe-X-Gly-Leu-Met-NH2, which is essential for its biological activity. NKA primarily interacts with the NK-2 receptor, a G-protein coupled receptor localized on smooth muscle cells. The NK-2 receptor is part of the rhodopsin superfamily, featuring seven transmembrane domains that are highly conserved across species, indicating stringent evolutionary constraints.

    The human NK-2 receptor gene spans approximately 20 kilobases and consists of five exons interrupted by four introns. The coding sequence is extended by 14 amino acids at the COOH-terminus compared to bovine and by 9 residues compared to rat. NKA and its receptor are prominently expressed in smooth muscle-containing tissues, such as those in the gastrointestinal, respiratory, and vascular systems, where they play a significant role in mediating physiological responses.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Gerard NP, Eddy RL Jr, Shows TB, Gerard C. The human neurokinin A (substance K) receptor. Molecular cloning of the gene, chromosome localization, and isolation of cDNA from tracheal and gastric tissues. J Biol Chem. 1990 Nov 25;265(33):20455-62. Erratum in: J Biol Chem. 1991 Jan 15;266(2):1354. PMID: 2173708.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"