Recombinant NENF protein (His tag)

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Recombinant Human Neudesin Fragment (45-172) is a highly stable and soluble protein fragment derived from the neuron-derived neurotrophic factor, designed for structural and biochemical studies. This fragment retains key functional characteristics, making it an ideal tool for investigating neurotrophic signaling pathways and neuronal survival mechanisms.

Neudesin, encoded by the NENF gene in Homo sapiens, functions as a neurotrophic factor that enhances neuronal survival in mature postnatal neurons and promotes cell proliferation and neurogenesis in undifferentiated neural progenitor cells during embryonic development. It inhibits astrocyte differentiation and exerts its neurotrophic effects through MAPK1/ERK2, MAPK3/ERK1, and AKT1/AKT signaling pathways, with activity enhanced by heme binding. Additionally, Neudesin acts as an anorexigenic neurotrophic factor involved in energy balance regulation. The protein localizes to the secreted extracellular space, mitochondria, and endoplasmic reticulum, with mitochondrial and endoplasmic reticulum localization mediated by PINK1 and PARK7. This fragment (residues 45-172) was selected for its stability and solubility, enabling focused research on Neudesin's functional domains.