Recombinant NEK7 protein (His tag)

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Recombinant Human Serine/threonine-protein kinase Nek7 (NEK7) fragment (residues 1-302) is a high-purity protein encompassing the complete kinase domain. This product is an essential tool for investigating mitotic regulation, microtubule nucleation, and NLRP3 inflammasome activation, offering researchers a targeted reagent for functional and mechanistic studies.

Serine/threonine-protein kinase Nek7 is a critical regulator of mitotic progression, required for centrosome-mediated microtubule nucleation, spindle formation, and cytokinesis. It phosphorylates substrates such as EML4 to promote chromosome congression and functions as an essential activator of NLRP3 inflammasome assembly independently of its kinase activity. Nek7 localizes to the nucleus, cytoplasm, spindle poles, and centrosome throughout the cell cycle, with its interaction partners like NEK9 ensuring mutual exclusivity between inflammasome activation and cell division. This protein plays dual roles in cell cycle control and innate immunity, making it significant for studying cellular division and inflammatory responses.