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Product Name
Recombinant NEK1 protein (His tag)
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Description
Recombinant Human Serine/threonine-protein kinase Nek1 (NEK1) fragment (amino acids 1-275) is a high-purity protein encompassing the complete protein kinase domain. This product is an essential tool for investigating kinase activity, DNA damage response, and ciliary assembly mechanisms in cellular and biochemical assays.
Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) is a multifunctional kinase involved in critical cellular processes including DNA damage checkpoint control and DNA damage repair. It phosphorylates VDAC1 to limit mitochondrial cell death in response to DNA damage and plays a role in cilium assembly. The protein localizes to the nucleus, cytoplasm, centrosome, and microtubule organizing center, and translocates to nuclear foci at DNA damage sites. Its involvement in meiosis regulation and centrosomal function makes it significant for studying cell cycle control, DNA repair pathways, and ciliopathy-related disorders.
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Protein name
Serine/threonine-protein kinase Nek1
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Uniprot ID
Q96PY6
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Gene Name
NEK1; KIAA1901
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-275 aa (Q96PY6) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 33.26 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 34 kDa band.
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Purity
>87%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"