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Product Name
Recombinant NDUV2 protein (His tag)
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Description
This recombinant protein is a 212-amino acid fragment (residues 38-249) of the human NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (NDUFV2), a key subunit of mitochondrial Complex I. The fragment has been computationally optimized for stability and solubility, making it ideal for structural studies and biochemical assays investigating electron transport mechanisms.
NDUFV2 is a core subunit of mitochondrial Complex I (NADH-ubiquinone oxidoreductase), which catalyzes electron transfer from NADH to ubiquinone in the respiratory chain. It forms part of the enzyme's peripheral arm, where electrons are accepted by flavin mononucleotide (FMN) and transferred via iron-sulfur clusters through electron tunneling to ubiquinone. The protein localizes to the matrix side of the mitochondrial inner membrane as a peripheral membrane protein, playing an essential role in cellular energy production through oxidative phosphorylation.
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Protein name
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
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Uniprot ID
P19404
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Gene Name
NDUFV2
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 38-249 aa (P19404) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 25.10 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 25 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"