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Recombinant NAGA protein (His tag)

Recombinant NAGA protein (His tag)

Cat.#: 548566

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Product Information

  • Product Name
    Recombinant NAGA protein (His tag)
  • Documents
  • Description

    Recombinant Human N-acetylglucosamine-6-phosphate deacetylase (GlcNAc 6-P deacetylase), encoded by the AMDHD2 gene, is a high-purity protein fragment (residues 1-409) designed for structural and functional studies. This fragment encompasses the complete amidohydrolase domain, optimized for stability and solubility, making it ideal for investigating enzymatic activity in the N-glycolylneuraminic acid degradation pathway.

    The full-length N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) plays a critical role in hydrolyzing the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) during the degradation of N-glycolylneuraminic acid (Neu5Gc). Although humans cannot synthesize Neu5Gc due to an inactive CMAHP enzyme, this dietary compound must be metabolized, underscoring the enzyme's importance in detoxification and metabolic processing. The provided fragment represents a functionally relevant unit for elucidating these mechanisms in biochemical assays.

  • Protein name
    N-acetylglucosamine-6-phosphate deacetylase
  • Uniprot ID
    Q9Y303
  • Gene Name
    AMDHD2
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    DNA encoding 1-409 aa (Q9Y303) were fused with 6His tag.
  • Protein Species
    Human
  • Molecular weight
    Predictes a molecular mass of 45.41 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 45 kDa band.
  • Purity
    >86%, by SDS-PAGE with Coomassie Brilliant Blue staining.
  • Activity
    Not tested.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"