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Product Name
Recombinant MYO5A protein (His tag)
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Description
Recombinant Human Unconventional Myosin-Va Fragment (residues 634-1076) is a high-purity protein designed for studying the IQ domain-mediated functions of this processive actin-based motor protein. This 443-amino acid fragment contains six consecutive IQ motifs (IQ 1-6), making it an ideal tool for investigating calcium-sensitive interactions and motor protein regulation in cellular transport processes.
Unconventional myosin-Va is a processive actin-based motor protein that moves in large steps along actin filaments and hydrolyzes ATP in an actin-dependent manner. This protein plays crucial roles in intracellular transport, including melanosome movement and vesicle transport to the plasma membrane. Evidence also suggests involvement in polarization processes during dendrite formation. The full-length protein functions as a molecular motor essential for various cellular transport mechanisms, though specific subcellular localization data is not provided in the available information.
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Protein name
Unconventional myosin-Va
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Uniprot ID
Q9Y4I1
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Gene Name
MYO5A; MYH12
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 634-1076 aa (Q9Y4I1) were fused with 6His tag.
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Sequence
634-1076
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 54.98 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 55 kDa band.
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Purity
>87%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"