Recombinant MYC protein (His tag)

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Recombinant Human Myc proto-oncogene protein fragment (residues 364-454), encompassing the essential basic helix-loop-helix (bHLH) domain. This high-purity fragment serves as an ideal tool for investigating DNA-binding mechanisms, transcriptional regulation, and domain-specific functions of the c-Myc oncoprotein in cellular growth and reprogramming studies.

The full-length Myc proto-oncogene protein (c-Myc) is a master transcription factor that binds DNA non-specifically while recognizing the core sequence 5'-CAC[GA]TG-3'. It activates growth-related genes and promotes processes such as VEGFA-mediated angiogenesis and somatic reprogramming. c-Myc collaborates with TAF6L to regulate RNA polymerase II pause release and influences splicing factors like HNRNPA1 to control pyruvate kinase isoform production. Localized primarily in the nucleus and nucleoplasm, with additional presence in nucleoli, cytoplasm, and chromatin, its subcellular distribution is modulated by phosphorylation and interactions with proteins like HEATR1. As a central regulator of cell proliferation and stem cell self-renewal, c-Myc is critically implicated in oncogenesis and developmental biology.