Recombinant MPPB protein (His tag)

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Recombinant Mitochondrial-processing peptidase subunit beta (EC 3.4.24.64), a catalytic subunit of the essential mitochondrial processing protease (MPP), is available as a stable and soluble fragment (residues 55-489). This product is ideal for structural studies, biochemical assays, and investigating mitochondrial protein import and processing mechanisms.

The full-length Mitochondrial-processing peptidase subunit beta (encoded by the PMPCB gene) is a key catalytic component of the mitochondrial processing protease (MPP), which is essential for cleaving mitochondrial targeting sequences from newly imported precursor proteins. It preferentially cleaves after an arginine at position P2 and is localized in the mitochondrial matrix. This enzyme is also involved in the turnover of PINK1 by coupling its mitochondrial import and cleavage, a process critical for mitochondrial quality control. The provided recombinant fragment (residues 55-489) was computationally selected to ensure stability and solubility, facilitating research into its structural and functional properties.