Mouse Klk7/Prss6/Scce (His tag) recombinant protein

Mouse Klk7/Prss6/Scce (His tag) recombinant protein

• DataSheet
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Kallikrein7, also named as stratum corneum chymotryptic enzyme (SCCE), is a secreted protein of the Kallikrein-related peptidase (KLK) family. This family contains fifteen homologous secreted serine endopeptidases and plays a significant role in various physiological processes, including skin desquamation, semen liquefaction, neural plasticity, and body fluid homeostasis. In skin KLK5, KLK 7 and KLK14 are able to degrade corneodesmosomes, which leads to desquamation of skin surface cells. KLK activation is believed to be mediated through highly organized proteolytic cascades, regulated through a series of feedback loops, inhibitors, auto-degradation and internal cleavages. Studies have shown that one potential physiological activator for KLK7 is KLK5. Along with KLK14, these three kallikreins form a proteolytic cascade in the stratum corneum. KLK7 is primarily expressed in the skin but is also detected at relatively high levels in esophagus, heart, liver, central nervous system, kidney, pancreas, mammary and salivary glands.

kallikrein related-peptidase 7 (chymotryptic, stratum corneum)(Klk7)

Prss6; Scce

Q91VE3

Human Cells

A DNA sequence encoding the Mouse Klk7/Prss6/Scce Gln22-Arg249 is expressed with a 6His tag at the C-terminus.

Mouse

>95% as determined by SDS-PAGE.