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Mouse JAML/AMICA1 (Fc Tag) recombinant protein

Cat.#: 504025

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Product Information

  • Product Name
    Mouse JAML/AMICA1 (Fc Tag) recombinant protein
  • Documents
  • Description
    Junctional adhesion molecules (JAMs) are endothelial and epithelial adhesion molecules involved in the recruitment of circulating leukocytes to inflammatory sites. JAML (Junctional adhesion molecule-like), also known as AMICA1 (Adhesion molecule interacting with CXADR antigen 1), a protein related to the JAM family, is restricted to leukocytes and promotes their adhesion to endothelial cells. It contains 2 extracellular immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic tail involved in activation signaling. Monocytic JAML/AMICA1 plays a critical role in regulating monocyte transendothelial migration (TEM) probably via binding to the endothelial coxsackie and adenovirus receptor (CAR) and other tight junction-associated adhesive molecules. The Expression of JAML/AMICA1 is restricted to the hematopoietic tissues with the exception of liver. JAML may function in transmigration of leukocytes through epithelial and endothelial tissues. Expressed at the plasma membrane of polymorphonuclear leukocytes, JAML/AMICA1 also enhances myeloid leukemia cell adhesion to endothelial cells.
  • Protein name
    Junctional adhesion molecule-like
  • Protein short names
    ADHESION MOLECULE INTERACTING WITH CXADR ANTIGEN 1; CREA7-4; AMICA1; CREA7; ADHESION MOLECULE THAT INTERACTS WITH CXADR ANTIGEN 1; DENDRITIC CELL-SPECIFIC PROTEIN CREA7-1; AMICA; JUNCTIONAL ADHESION MOLECULE-LIKE; JAML; DENDRITIC-CELL SPECIFIC PROTEIN CREA7-4; FLJ37080; UNQ722/PRO1387; MCREA7; MGC118815; ADHESION MOLECULE AMICA; ADHESION MOLECULE; MGC118814; CREA7-1; DENDRITIC CELL-SPECIFIC PROTEIN CREA7; JUNCTIONAL ADHESION MOLECULE; INTERACTS WITH CXADR ANTIGEN 1; GM638
  • Uniprot ID
    Q80UL9
  • Gene Name
    Amica1; Gm638; Jaml
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mouse (NP_001005421.3) (Met1-Leu281) was expressed with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The recombinant mouse consists 500 amino acids and predicts a molecular mass of 56.5 kDa.
  • Purity
    > (7.3+91.7) % as determined by SDS-PAGE.
  • Validations

    Mouse JAML / AMICA1 Protein (Fc Tag) SDS-PAGE

    Mouse JAML / AMICA1 Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"