Recombinant MORC3 protein (His tag)

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Recombinant Human MORC3 Protein (aa 1-464) is a high-quality, soluble fragment of the nuclear matrix protein MORC family CW-type zinc finger protein 3, designed for structural and biochemical studies. This fragment retains key functional characteristics, offering researchers a reliable tool to investigate MORC3's roles in innate immunity, histone methylation reading, and viral restriction mechanisms.

MORC3 is a nuclear matrix protein that forms ATP-dependent nuclear bodies (MORC3-NBs) and plays a critical role in innate immunity by restricting various viruses through modulation of the interferon (IFN) response. It exhibits a dual regulatory function, primarily activating IFNB1 via a MORC3-regulated element while also repressing IFN signaling as a secondary mechanism. MORC3 interacts with PML nuclear bodies, recruiting TP53 and SP100 to regulate TP53 activity, and functions as a histone methylation reader with binding preference for H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0. Additionally, it may support influenza A virus transcription during infection. The protein localizes to the nucleus, nucleoplasm, nuclear matrix, PML bodies, and chromosomes, with its nuclear body localization being ATP-dependent.