Recombinant MOG protein (His tag)

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Recombinant Human Myelin-oligodendrocyte glycoprotein (MOG) Fragment (aa 30-154) is a high-purity protein designed for neuroscience and immunology research. This 125-amino acid fragment fully encompasses the Ig-like V-type domain (aa 32-145), making it an ideal tool for studying homophilic cell adhesion, myelin sheath maintenance, and viral receptor interactions in a controlled experimental context.

Myelin-oligodendrocyte glycoprotein (MOG), encoded by the MOG gene in humans, is a minor but functionally significant component of the myelin sheath. It mediates homophilic cell-cell adhesion and is implicated in the completion and maintenance of the myelin sheath, facilitating cell-cell communication within the nervous system. Additionally, MOG serves as a receptor for rubella virus, highlighting its role in microbial infection pathways. The protein localizes to the cell membrane, with multiple isoforms existing as either multi-pass or single-pass type I membrane proteins. The recombinant fragment (aa 30-154) focuses on the Ig-like V-type domain, enabling targeted investigation of these critical functions without interference from full-length protein complexity.