-
Product Name
Recombinant MIEN1 protein (His tag)
- Documents
-
Description
This recombinant protein product features a stable and soluble fragment (residues 2-112) of Human Migration and invasion enhancer 1 (MIEN1), also known as Protein C35. This fragment has been computationally optimized for structural and biochemical studies, offering researchers a reliable tool to investigate MIEN1's role in cell migration, invasion, and apoptosis regulation.
Migration and invasion enhancer 1 (MIEN1) is a human protein that enhances cell migration by promoting filopodia formation at the leading edge of migrating cells. It also plays a role in apoptosis regulation, potentially through control of CASP3, and may be involved in redox-related processes. MIEN1 localizes to the cytoplasm and cytosol, and associates with the cell membrane via lipid anchors on the cytoplasmic side, concentrating at the leading edge during cell migration while residing outside membrane raft regions. This strategic localization supports its function in directing cellular movement and signaling pathways.
-
Protein name
Migration and invasion enhancer 1
-
Uniprot ID
Q9BRT3
-
Gene Name
MIEN1; C17orf37; RDX12; XTP4
-
Source/Expression Host
E. coli
-
Expression Plasmid/cDNA
DNA encoding 2-112 aa (Q9BRT3) were fused with C-terminal 6His tag.
-
Sequence
MSKIKSGEPG QTSVAPPPEE VEPGSGVRIV VEYCEPCGFE ATYLELASAV KEQYPGIEIE SRLGGTGAFE IEINGQLVFS KLENGGFPYE KDLIEAIRRA SNGETLEKIT NSRPPCLEHH HHHH
-
Protein Species
Human
-
Molecular weight
Predictes a molecular mass of 13.58 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 15 kDa band.
-
Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
-
Activity
Not tested.
-
Validations
Recombinant MIEN1 protein (His tag) SDS-PAGE
M: Marker; Lane 1: MIEN1; Lane 2: BSA
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"