Recombinant MICA protein (His tag)

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• Material Safety Data Sheets (MSDS)

Recombinant Human MIC-A Protein (Fragment 24-307) is a high-purity, functional fragment of the MHC class I polypeptide-related sequence A (MICA), encompassing the Ig-like C1-type domain. This fragment serves as a critical ligand for NKG2D receptors, enabling researchers to study immune activation mechanisms in stress-related cellular responses.

MICA is a membrane-bound protein expressed in various human tissues that functions as a ligand for the activating receptor KLRK1/NKG2D on natural killer (NK) cells, γδ T cells, and CD8 αβ T cells. It is upregulated during cellular stress conditions, including viral and bacterial infections or DNA damage, where it signals distress to immune cells. Engagement of MICA with NKG2D triggers cytotoxic responses and cytokine production, playing a pivotal role in immune surveillance. MICA is primarily localized to the cell membrane as a single-pass type I protein, though it can also be found in the cytoplasm in certain cell types, and its surface expression can be modulated by viral infections such as adenovirus.