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  • Melittin (Apis dorsata) peptide

Melittin (Apis dorsata) peptide

Not For Human Use, Lab Use Only.

Cat.#: 303921

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Product Information

  • Product Name
    Melittin (Apis dorsata) peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    GIGAILKVLSTGLPALISWIKRKRQE
  • Sequence
    H-Gly-Ile-Gly-Ala-Ile-Leu-Lys-Val-Leu-Ser-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Glu-NH2
  • Length (aa)
    26
  • Peptide Purity (HPLC)
    96.3%
  • Molecular Formula
    C131H228N38O32
  • Molecular Weight
    2847.4
  • Source
    Synthetic
  • Form
    Powder
  • Description

    Melittin is the principal component of bee venom. It is a peptide consisting of 26 amino acid residues. The amino acid sequence of melittin has been characterized from four species within the genus Apis: A. mellifera, A. cerana, A. dorsata, and A. florea. The sequences from A. mellifera and A. cerana are identical. In contrast, the melittin from A. dorsata differs by three residues from the mellifera/cerana sequence, while the A. florea melittin differs by five residues. A notable structural feature of A. dorsata melittin is the presence of a free carboxyl group in its C-terminal glutaminyl-isoglutamine sequence, unlike the other variants.

    The sequence variations among these melittins provide insights into phylogenetic relationships. The closer similarity of A. dorsata melittin to that of A. mellifera and A. cerana, compared to A. florea, suggests a molecular alignment where A. florea diverged earlier in evolution. The primary structure of melittin thus serves as a molecular marker for deducing evolutionary pathways within honeybees.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Kreil G. The structure of Apis dorsata melittin: phylogenetic relationships between honeybees as deduced from sequence data. FEBS Lett. 1975 Jun 1;54(1):100-2. doi: 10.1016/0014-5793(75)81079-9. PMID: 1093875.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

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  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"