Recombinant MEF2C protein (His tag)

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Recombinant Human Myocyte-specific enhancer factor 2C (MEF2C) fragment (amino acids 1-130) is a high-purity protein designed for studying the MADS-box domain's role in transcriptional regulation, muscle development, and neuronal function. This fragment serves as an essential tool for researchers investigating specific domain functions in gene expression and cellular differentiation.

Myocyte-specific enhancer factor 2C (MEF2C) is a transcription activator that binds to the MEF2 element in muscle-specific gene regulatory regions. It plays critical roles in cardiac morphogenesis, myogenesis, vascular development, and synaptic regulation in the hippocampus and neocortex. MEF2C is also essential for megakaryocyte and platelet development, B-cell survival, and antibody responses. The protein localizes to the nucleus and cytoplasm/sarcoplasm, underscoring its diverse functional impact. The provided fragment (1-130) contains the MADS-box domain (residues 3-57), enabling focused studies on this key regulatory region's mechanisms.