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Product Name
Recombinant MECP2 protein (His tag)
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Description
Recombinant Human Methyl-CpG-binding protein 2 (MeCp2) Fragment (aa 92-175) is a highly stable and soluble protein unit designed for structural and biochemical studies. This 84-amino acid fragment enables researchers to investigate the DNA-binding mechanisms of MeCp2, a key epigenetic regulator, in a manageable and functional format.
Methyl-CpG-binding protein 2 (MeCp2) is a chromosomal protein that specifically binds to methylated DNA, recognizing single methyl-CpG pairs without influence from flanking sequences. It mediates transcriptional repression by interacting with histone deacetylase and the corepressor SIN3A, playing a critical role in epigenetic regulation. MeCp2 binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5mC. The protein is localized in the nucleus, where it colocalizes with methyl-CpG in the genome and with TBL1X at heterochromatin foci, underscoring its importance in chromatin organization and gene silencing.
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Protein name
Methyl-CpG-binding protein 2
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Uniprot ID
P51608
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Gene Name
MECP2
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 92-175 aa (P51608) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 11.20 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 11 kDa band.
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Purity
>89%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"