MCRS1 antibody

MCRS1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

MCRS1 Mouse Monoclonal antibody. Positive WB detected in Skov-3 cells. Observed molecular weight by Western-blot: 55+110KD

ELISA, WB

Human,Mouse; other species not tested.

58 kDa microspherule protein antibody; ICP22BP antibody; INO80 complex subunit J antibody; INO80Q antibody; MCRS1 antibody; MCRS2 antibody; microspherule protein 1 antibody; MSP58 antibody; P78 antibody

Mouse IgG2a

This antibody was obtained by immunization of MCRS1 recombinant protein (Accession Number: NM_006337). Purification method: Protein A purified.

Monoclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

MCRS1, also named INO80Q, MSP58 or p78, is a nucleolar protein expressed in the very early S phase. It modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. MCRS1 is also present on polyribosomes of synaptoneurosome as a novel RNA-binding protein to activate the rRNA transcription. The forkhead-associated domain of MCRS1 is involved in association with centrosomal protein Nde1, comprising a component of the centrosome and taking an essential role in viability. Its isoform MCRS2 might be a linker between telomere maintenance and cell-cycle regulation by interacting with LPTS/PinX1, a telomerase-inhibitory protein. MCRS1 is detected by Western blot as a highly modified protein at 78 kDa and minor bands at about 62 and 55 kDa.