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Product Name
Human MMP-9/MMP9 recombinant protein
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Description
May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.
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Protein name
Matrix metalloproteinase-9
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Protein short names
RP23-61O3.10; PRO-MMP-9; MANDP2; GELB; AW743869; MMP9; B/MMP9; CLG4B; MMP-9
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Uniprot ID
P14780
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Gene Name
MMP9; CLG4B
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human MMP9 zymogen (NP_004985.2) (Met 1-Asp 707) was expressed.
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Protein Species
Human
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Molecular weight
The recombinant human MMP9 consisting of 688 amino acids has a predicted molecular mass of 76.3 kDa. The apparent molecular mass of rh MMP9 is approximately 80-95 kDa in SDS-PAGE due to glycosylation.
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Purity
> 94 % as determined by SDS-PAGE
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Activity
Measured by its ability to cleave the fluorogenic peptide substrate, Mca-PLGL-Dpa-AR-NH2, (AnaSpec, Cat#27076). The specific activity is >600 pmoles/min/μg.
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Validations
Human MMP-9 / CLG4B Protein SDS-PAGE
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