Recombinant MAT1 protein (His tag)

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Recombinant human CDK-activating kinase assembly factor MAT1 fragment (residues 1-209), encompassing the UIM functional domain. This high-quality protein is an essential tool for investigating the assembly and regulatory mechanisms of the CDK-activating kinase complex, supporting studies in cell cycle control and transcription.

The full-length CDK-activating kinase assembly factor MAT1 (encoded by the MNAT1 gene) stabilizes the cyclin H-CDK7 complex to form the functional CDK-activating kinase (CAK). CAK activates cyclin-dependent kinases CDK1, CDK2, CDK4, and CDK6 via threonine phosphorylation, playing a critical role in cell cycle progression. Additionally, when complexed with the core-TFIIH basal transcription factor, CAK phosphorylates the C-terminal domain of RNA polymerase II, facilitating transcription initiation and elongation. This protein is localized to the nucleus, underscoring its importance in nuclear events related to gene expression and cell division control.