Recombinant MAPK2 protein (His tag)

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Recombinant Human MAPKAPK2 (1-400) is a high-purity protein fragment encompassing the complete kinase domain of MAP kinase-activated protein kinase 2. This fragment provides researchers with a functional tool to study stress-activated signaling pathways, cytokine regulation, and cellular stress responses without interference from regulatory regions.

MAPKAPK2 is a stress-activated serine/threonine-protein kinase that plays crucial roles in cytokine production, cytoskeleton reorganization, cell migration, DNA damage response, and transcriptional regulation. Activated by p38-alpha/MAPK14 following cellular stress, it phosphorylates numerous substrates including HSP27, TTP/ZFP36, and HNRNPA0 to regulate mRNA stability and translation. The protein shuttles between nucleus and cytoplasm, with phosphorylation-induced activation promoting its export from the nucleus. MAPKAPK2 is involved in inflammatory responses through post-transcriptional regulation of TNF and IL6 production, and functions in TLR signaling pathways and G2/M checkpoint control following DNA damage.