-
Product Name
Human MARK3/C-TAK1 (His & GST Tag) recombinant protein
- Documents
-
Description
Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus.
-
Protein name
MAP/microtubule affinity-regulating kinase 3
-
Protein short names
MARK3; EMK2; PAR-1A; CTAK1; ETK-1; MPK10; C-TAK1; KP78; KIAA4230; ETK1; PAR1A; 1600015G02RIK; EMK-2; A430080F22RIK
-
Uniprot ID
P27448
-
Gene Name
MARK3; CTAK1; EMK2
-
Source/Expression Host
Baculovirus-Insect Cells
-
Expression Plasmid/cDNA
A DNA sequence encoding full length of human MARK3 (AAH24773.1) (Met 1-Leu 729) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
-
Protein Species
Human
-
Molecular weight
The recombinant human MARK3/GST chimera consists of 967 amino acids and has a calculated molecular mass of 109.3 kDa. It migrates as an approximately 120 kDa band in SDS-PAGE under reducing conditions.
-
Purity
> 88 % as determined by SDS-PAGE
-
Activity
The specific activity was determined to be 7 nmol/min/mg using synthetic CHKtide peptide (KKKVSRSGLYRSPSMPENLNRPR) as substrate.
-
Validations
Human MARK3 / CTAK1 / EMK-2 Protein (His & GST Tag) SDS-PAGE
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"