Recombinant M3K7 protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Recombinant Human MAP3K7 (1-301) is a high-purity protein fragment encompassing the complete kinase domain (residues 36-291) of Mitogen-activated protein kinase kinase kinase 7 (MAP3K7/TAK1). This product is an essential tool for investigating kinase activity, signal transduction mechanisms, and pathway regulation in cellular stress, immune, and inflammatory responses.

MAP3K7 (also known as TGF-beta-activated kinase 1) is a serine/threonine kinase that serves as a critical regulator in the MAP kinase signaling pathway, mediating cellular responses to environmental stimuli. It transduces signals from various receptors, including TLRs, cytokine receptors (e.g., IL-1, TGFB), and B-cell receptors, leading to activation of downstream effectors such as JNK, p38 MAPK, and NF-kappa-B pathways. These cascades influence transcription factors like AP-1 and are pivotal in processes like necroptosis, immune defense, and osmotic stress signaling. The full-length protein is primarily localized in the cytoplasm and can associate with the cell membrane as part of a complex with adaptor proteins. The provided fragment (1-301) retains the functional kinase domain, enabling focused studies on its catalytic and regulatory roles without interference from other protein regions.