Recombinant LONM protein (His tag)

• DataSheet
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Recombinant Human LONP1 Protein Fragment (residues 117-220) is a high-quality, stable, and soluble product derived from the mitochondrial Lon protease homolog. This fragment is ideal for structural studies, biochemical assays, and functional investigations of mitochondrial protein quality control mechanisms.

The full-length Lon protease homolog (LONP1) is an ATP-dependent serine protease located in the mitochondrial matrix, essential for maintaining mitochondrial integrity. It selectively degrades misfolded, unassembled, or oxidatively damaged polypeptides, as well as short-lived regulatory proteins, including mitochondrial steroidogenic acute regulatory (StAR) protein, DELE1, helicase Twinkle (TWNK), and the ribosomal protein MRPL32/bL32m. LONP1 also exhibits chaperone activity in assembling inner membrane protein complexes and plays a critical role in regulating mitochondrial gene expression and genome integrity by binding to mitochondrial promoters and RNA in a site-specific manner. This protein ensures mitochondrial proteostasis and supports cellular energy metabolism and stress responses.