Recombinant LMCD1 protein (His tag)

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Recombinant Human LMCD1 (Dyxin) Fragment (aa 239-365) is a high-purity protein designed for studying the specific functions of the LIM zinc-binding domains 1 and 2. This fragment serves as an essential tool for researchers investigating transcriptional regulation, cardiac hypertrophy signaling, and GATA6-mediated pathways in human cellular systems.

The full-length LIM and cysteine-rich domains protein 1 (LMCD1), encoded by the LMCD1 gene in Homo sapiens, functions as a transcriptional cofactor that restricts GATA6 activity by inhibiting DNA-binding, thereby repressing GATA6-driven transcriptional activation of downstream genes. It plays a critical role in repressing GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters and is involved in cardiac hypertrophy development through activation of the calcineurin/nuclear factor of activated T-cells signaling pathway. The protein localizes to both the cytoplasm and nucleus, with evidence suggesting it may shuttle between these compartments, highlighting its dynamic role in cellular regulation and signaling processes.