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Product Name
Recombinant LIRB3 protein (His tag)
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Description
Recombinant Human LILRB3 (CD85a/ILT-5) Fragment (aa 24-443) – a high-purity protein designed for investigating immune regulation, featuring the complete extracellular Ig-like domains essential for MHC class I binding and inhibitory signaling in B-cell activation studies.
Leukocyte immunoglobulin-like receptor subfamily B member 3 (LILRB3), also known as CD85a or ILT-5, is a transmembrane receptor that recognizes class I MHC antigens and modulates immune responses. Upon co-ligation with receptors like FCGR2B and the B-cell receptor, LILRB3 becomes activated and downregulates antigen-induced B-cell activation by recruiting phosphatases via its immunoreceptor tyrosine-based inhibitor motifs (ITIMs). As a single-pass type I membrane protein localized to the cell membrane, it plays a critical role in fine-tuning immune activation and tolerance mechanisms.
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Protein name
Leukocyte immunoglobulin-like receptor subfamily B member 3
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Uniprot ID
O75022
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Gene Name
LILRB3; ILT5; LIR3
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 24-443 aa (O75022) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 47.73 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 48 kDa band.
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Purity
>89%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"