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Product Name
Recombinant LIN59 protein (His tag)
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Description
Recombinant fragment of Probable histone-lysine N-methyltransferase lin-59 from Caenorhabditis elegans, encompassing amino acids 569-773. This high-purity fragment contains the complete AWS and SET functional domains, making it an essential tool for studying histone methylation mechanisms and chromatin regulation in developmental biology research.
The full-length lin-59 protein is a probable histone methyltransferase localized to the nucleus. It functions as an essential regulator required to maintain expression of homeotic genes egl-5 and mab-5, playing a role analogous to trithorax Group (trxG) proteins. These multiprotein complexes maintain the transcriptionally active state of homeotic genes throughout development, primarily through chromatin modification mechanisms. The protein's nuclear localization and chromatin-modifying activity position it as a key player in epigenetic regulation and developmental gene expression programs.
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Protein name
Probable histone-lysine N-methyltransferase lin-59
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Uniprot ID
O44757
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Gene Name
lin-59
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 569-773 aa (O44757) were fused with 6His tag.
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Protein Species
Caenorhabditis elegans
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Molecular weight
Predictes a molecular mass of 24.50 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 24 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"