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Product Name
Recombinant LICH protein (His tag)
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Description
Recombinant Human Lysosomal Acid Lipase/Cholesteryl Ester Hydrolase (LAL) Fragment (residues 77-399) is a high-purity protein designed for studying lipid metabolism and lysosomal function. This fragment fully encompasses the AB hydrolase-1 domain, making it an ideal tool for investigating specific enzymatic activities and domain functions in cholesterol and triglyceride hydrolysis.
Lysosomal acid lipase/cholesteryl ester hydrolase (LAL), encoded by the LIPA gene, is a crucial enzyme localized in lysosomes. It catalyzes the hydrolysis of cholesteryl esters from endocytosed low-density lipoproteins, generating free fatty acids and cholesterol for cellular use. Additionally, LAL hydrolyzes triglycerides and diglycerides, showing preference for acyl moieties at the sn-1 or sn-3 positions. This enzyme plays a vital role in lipid metabolism and cholesterol homeostasis, with implications in understanding lysosomal storage disorders and cardiovascular diseases.
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Protein name
Lysosomal acid lipase/cholesteryl ester hydrolase
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Uniprot ID
P38571
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Gene Name
LIPA
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 77-399 aa (P38571) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 38.47 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 38 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"