Recombinant LGUL protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

This recombinant protein product features a functional fragment (residues 2-184) of human Lactoylglutathione lyase (Glyoxalase I), encoded by the GLO1 gene. It encompasses the complete VOC domain, making it an ideal tool for investigating the enzyme's catalytic activity in methylglyoxal detoxification and its regulatory roles in cellular signaling pathways.

Lactoylglutathione lyase (EC 4.4.1.5), also known as Glyoxalase I, is a critical enzyme in the glyoxalase system, catalyzing the isomerization of hemimercaptal (formed from methylglyoxal and glutathione) to S-lactoylglutathione. This reaction is essential for detoxifying methylglyoxal, a reactive dicarbonyl compound generated during glycolysis. Beyond its metabolic role, the enzyme regulates TNF-induced NF-kappa-B transcriptional activity and is required for normal osteoclastogenesis, implicating it in inflammatory responses and bone remodeling processes. The provided fragment retains key functional domains necessary for studying these specific biochemical and cellular functions.

2-184