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Product Name
Recombinant LARP6 protein (His tag)
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Description
Recombinant Human La-related protein 6 (LARP6) Fragment (aa 86-291) is a high-purity protein designed for investigating the RNA-binding activity of the HTH La-type domain. This fragment serves as an essential tool for studying the molecular mechanisms of collagen mRNA regulation and stability.
La-related protein 6 (LARP6), also known as Acheron, is a key regulator of type I collagen synthesis in humans. It functions by binding to a specific stem-loop structure in the 5' UTR of collagen alpha-1 and alpha-2 mRNAs (COL1A1 and COL1A2), coordinating their translation and stabilizing the transcripts. This process involves interactions with VIM, MYH10 filaments, and the helicase DHX9. LARP6 localizes to both the cytoplasm and nucleus, shuttling between these compartments, highlighting its dynamic role in post-transcriptional gene regulation and cellular homeostasis.
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Protein name
La-related protein 6
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Uniprot ID
Q9BRS8
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Gene Name
LARP6
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 86-291 aa (Q9BRS8) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 25.55 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 26 kDa band.
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Purity
>85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"