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  • LAP3 antibody
  • LAP3 antibody
  • LAP3 antibody

LAP3 antibody

Cat.#: 112142

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Product Information

  • Product Name
    LAP3 antibody
  • Documents
  • Description
    LAP3 Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, HepG2 cells, mouse heart tissue, SH-SY5Y cells. Positive IHC detected in human gliomas tissue. Observed molecular weight by Western-blot: 56kd
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    Cytosol aminopeptidase antibody; LAP antibody; LAP 3 antibody; LAP3 antibody; LAPEP antibody; leucine aminopeptidase 3 antibody; Leucyl aminopeptidase antibody; PEPS antibody; Peptidase S antibody; Proline aminopeptidase antibody; Prolyl aminopeptidase antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of LAP3 recombinant protein (Accession Number: BC065564). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:112142(LAP3 antibody) at dilution of 1:300

    HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:112142(LAP3 antibody) at dilution of 1:300

    Immunohistochemical of paraffin-embedded human gliomas using Catalog No:112142(LAP3 antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human gliomas using Catalog No:112142(LAP3 antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human gliomas using Catalog No:112142(LAP3 antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemical of paraffin-embedded human gliomas using Catalog No:112142(LAP3 antibody) at dilution of 1:50 (under 40x lens)

  • Background
    LAP3(Leucine aminopeptidase 3) is also named as LAPEP, PEPS(peptidase S) and belongs to the peptidase M17 family. It can catalyzes the removal of unsubstituted N-terminal amino-acids from various peptides and be presumably involved in the processing end regular turnover of intracellular proteins. PEPS is found in a wide variety of tissues and cultured cells but not in red cells and skin. The enzyme can utilize several di-, tri-, and tetrapeptides as substrates and is the slowest migrating of the peptidases after electrophoresis.(PMID:689684).
  • References
    • Zhu Z, Xu W, Dai J. The alteration of protein profile induced by cigarette smoking via oxidative stress in mice epididymis. The international journal of biochemistry & cell biology. 45(3):571-82. 2013.
    • Huang S, Cui Y, Guo X. 2,2',4,4'-Tetrabromodiphenyl ether disrupts spermatogenesis, impairs mitochondrial function and induces apoptosis of early leptotene spermatocytes in rats. Reproductive toxicology (Elmsford, N.Y.). 51:114-24. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"